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Parkinson's Disease: Molecular and Therapeutic Insights from Model Systems

Nass, Richard

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Book Information
Edition:	1st
Publisher:	Academic Press, Incorporated
ISBN:	0-08-055958-1 (0080559581)
ISBN-13:	978-0-08-055958-2 (9780080559582)
Binding:	E E Book + ProQuest Ebook Central
Copyright:	2008
Publish Date:	08/08
Weight:	0.00 Lbs.
Carton Quantity:	10
Subject Class:	NEU (Neurology and Neuroscience)
Return Policy:	Non-Returnable.
Table Of Contents:	View

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Class Specifications
Discipline:	Nervous Sys
Subject Definition:	Parkinson Disease
NLM Class:	WL 359
LC Class:	RC382
Abstract:	Parkinsons disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this book, the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death will be described, as well as the opportunities that these systems provide in drug discovery.

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