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| Available: 0 |
| Tentative Price:$165.00 |
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| Edition: | 1st |
| Publisher: | Academic Press, Incorporated |
| ISBN: | 0-12-824491-7 (0128244917) |
| ISBN-13: | 978-0-12-824491-3 (9780128244913) |
| Binding: | Softcover |
| Copyright: | 2022 |
| Weight: | 0.00 Lbs. |
| Pages: | 350 |
| Subject Class: | NEU (Neurology and Neuroscience) |
| Remarks: | This Title is Not Yet Published, Scheduled to Release 09/01/25 |
| Return Policy: | Returns accepted up to 90 days provided no other recalls or return restrictions apply. |
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| Abstract: | Acetylcholine in Alzheimer's disease and Related Dementias surveys the current state of knowledge on the cholinergic system in rodents, primates, including humans. The authors discuss aging and AD from the system, cellular, molecular and genetic aspects. The book critically evaluates the role of the cholinergic system as it relates to the clinical symptoms, therapy and pathogenesis. It follows the history of the cholinergic hypothesis of memory and AD from the seventies/early eighties of the previous century to the current view of disease-modifying role. It promotes the idea that the organization of the cholinergic system and its purported homeostatic role may contribute to its higher vulnerability to amyloid pathology of AD. Finally, it discusses current trends of AD prevention from the functional medicine perspective. Offers a comprehensive overview of the current state of knowledge on Alzheimer's and the cholinergic system Discusses basic molecular, cellular and system levels data of the basal forebrain cholinergic system as data relate to AD Synthesizes basic science such as anatomy, electrophysiology, pharmacology and genetics, with translational data from neurology, psychiatry and cognitive neuroscience |
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