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Actin Cytoskeleton in Cell Motility, Cancer, and Infection

Pardee, Joel D.

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Book Information
Edition:	1st
Publisher:	Morgan & Claypool Publishers
ISBN:	1-61504-007-2 (1615040072)
ISBN-13:	978-1-61504-007-0 (9781615040070)
Binding:	E E Book + ProQuest Ebook Central
Copyright:	2010
Publish Date:	04/10
Volume:	3
Weight:	0.00 Lbs.
Subject Class:	BCH (Biochemistry)
Return Policy:	Non-Returnable.

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Class Specifications
ISSN Series:	Colloquium Series in Medical Cell Biology
Discipline:	Biochemistry
Subject Definition:	Actins-Physiology; Cell Movement; Cells
NLM Class:	QU 300
LC Class:	QH647
Abstract:	The cell is no longer considered to be a bag full of enzymes dissolved in a liquid cytoplasm. It is now known that the cytoplasm is an exquisitely ordered structure of properly placed organelles and enzyme complexes that are suspended from an intricate network of structural protein polymers termed the cytoskeleton. All movement of organelles and vesicles within the cell is regulated by this cytoskeleton, and it is clear that the cytoskeleton is responsible for all of the cell's external movement as well. In this lecture, we will consider how the cytoskeleton elicits cell migration. The three main elements of the cytoskeleton are microtubules, intermediate filaments, and actin filaments. Intermediate filaments give structural integrity to virtually all cells and tissues by providing an intracellular network of flexible cables that strengthen internal cell structure and stabilize cell-to-cell adhesion. It is this intercellular binding property that stably joins epithelial cells together to provide the protective functions of skin and the integrity of the intestinal mucosa. Actin is a highly conserved protein ubiquitous to all eukaryotic cells. Actin filaments are also called thin filaments because of their very slender (70 A) diameter.

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